Table 4.
Meta-analysis results for PTPN22, MIF and TNFA variants and JIA
| |
|
Cases |
Controls |
|
|
|
||
|---|---|---|---|---|---|---|---|---|
| Gene | # Cases | MAF | # Controls | MAF | OR (95% CI) | p-value | Data sources | |
|
PTPN22 C1858T |
All Studies |
3261 |
0.14 |
4982 |
0.11 |
1.44 (1.31, 1.60) |
<0.0001 |
4-7, 18,19, 29 |
|
MIF G-173C |
Including Donn et al. [16] |
1382 |
0.19 |
1544 |
0.17 |
1.26 (1.09, 1.45) |
0.0356 |
9, 13, 16 |
| Removing Donn et al. |
856 |
0.19 |
1285 |
0.18 |
1.12 (0.96, 1.32) |
0.1548 |
|
|
|
TNFA G-238A |
Including Ozen et al. [22] |
1399 |
0.07 |
1648 |
0.07 |
0.84 (0.68, 1.04) |
0.1033 |
9, 11, 20, 22, 23 |
| Removing Ozen et al. |
1189 |
0.03 |
1455 |
0.04 |
0.69 (0.52, 0.91) |
0.0086 |
|
|
| TNFA G-308A | Including Ozen et al. [22] |
1583 |
0.17 |
1952 |
0.16 |
1.01 (0.88, 1.15) |
0.925 |
9, 11, 12, 20-23 |
| Removing Ozen et al. | 1373 | 0.15 | 1759 | 0.16 | 0.95 (0.83, 1.10) | 0.5137 | ||