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. 2013 Oct 29;11:81. doi: 10.1186/1478-811X-11-81

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Copyright © 2013 Santi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Silencing of CA IX in fibroblasts decreases tumor growth rate. Xenograft growth in SCID bg/bg mice of wild-type (control) or CA IX-silenced CAFs injected s.c. with PC3 cells (CAFs:PC3 cells ratio 1:5). CA IX silencing by RNA interference in fibroblasts is shown (Timepoint 14 days: ***, p < 0.01; timepoint 16 days: ****, p < 0.005). Linear regression equation of 'CAFs + PC3′’: y = 0.08065 (± 0.01035) x – 0.82478 (± 0.14473), R² = 0.9676; linear regression equation of 'CAFs CA IX sil + PC3′: y = 0.023219 (± 0.003469) x – 0.249096 (± 0.051038), R² = 0.9563.