Table 1.
Anti-plasmodial activity data
| |
Experimental IC
50
a
(nM) |
Experimental LD
50
a
(nM) |
||||
|---|---|---|---|---|---|---|
| Drug | HB3 | Dd2 | R f b | HB3 | Dd2 | R f b |
|
CQ |
23.8 (0.7) |
212.3 (9.0) |
9.0 |
120.0 (10.0) |
15300.0 (900.0) |
127.5 |
|
AQ |
10.1 (0.6) |
26.5 (0.4) |
2.6 |
37.2 (1.2) |
52.4 (2.3) |
1.4 |
|
PQ |
1990.0 (16.6) |
4695.0 (62.1) |
2.4 |
8640.0 (50.0) |
2810.0 (10.0) |
0.3 |
|
TQ |
2189.9 (18.7) |
2092.2 (20.0) |
1.0 |
42700.0 (2042.6) |
12100.0 (706.0) |
0.3 |
| MB | 5.3 (0.09) | 5.5 (0.07) | 1.0 | 120.2 (9.5) | 108.0 (6.6) | 0.9 |
aAverage of 3 independent measurements, each performed in triplicate (9 determinations total), with S.E.M. reported in parentheses.
bResistance factor (Rf) = Dd2 value/HB3 value.