Search date: August 26, 2012 Databases searched: Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Embase; Wiley; Cochrane; Centre for Reviews and Dissemination (CRD) database Limits: 2002-present; Human; English; NOT case reports, comments, editorials, letters Filters: RCTS & MAs/SRs/HTAs for administration route question (#3)
1	exp Vitamin B 12 Deficiency/ use mesz
2	exp Vitamin B 12/df use mesz
3	Transcobalamins/df use mesz
4	exp Cyanocobalamin Deficiency/ use emez
5	((b12 or b 12 or cyanocobalamin or cobalamin* or transcobalamin* or cobamide? or hydroxocobalamin or hydroxo-cobalamin or hydroxycobalamin) adj3 (deficien* or inadequa* or insufficien* or low blood level* or low serum level* or low plasma level* or suboptimal or sub-optimal or subnormal or sub-normal)).ti,ab.
6	(an?emia* adj2 (addison* or pernicious* or megaloblastic)).ti,ab.
7	or/1-6
8	exp Vitamin B 12/ use mesz
9	Transcobalamins/ use mesz
10	Transcobalamin/ use emez
11	Cyanocobalamin/ use emez
12	(b12 or b 12 or cyanocobalamin or cobalamin* or transcobalamin* or cobamide? or hydroxocobalamin or hydroxo-cobalamin or hydroxycobalamin).ti,ab.
13	or/8-12
14	exp Dementia/
15	exp Cognition Disorders/ use mesz
16	(alzheimer* or amentia? or dementia* or demention or senile or senility or (cognit* adj (decline or disorder? or impair*))).ti,ab.
17	or/14-16
18	(7 or 13) and 17
19	Case Reports/ or Comment.pt. or Editorial.pt. or Letter.pt.
20	Case Report/ or Comment/ or Editorial/ or Letter/
21	or/19-20
22	18 not 21
23	limit 22 to english language
24	limit 23 to yr="2002 -Current"
25	exp animals/
26	exp animal experimentation/
27	exp models animal/
28	exp animal experiment/
29	nonhuman/
30	exp vertebrate/
31	or/25-30
32	exp humans/
33	exp human experiment/
34	or/32-33
35	31 not 34
36	24 not 35
37	remove duplicates from 36
38	7 and 13
39	38 not 21
40	limit 39 to (controlled clinical trial or meta analysis or randomized controlled trial)
41	exp Technology Assessment, Biomedical/ or exp Evidence-based Medicine/ use mesz
42	exp Biomedical Technology Assessment/ or exp Evidence Based Medicine/ use emez
43	(health technology adj2 assess$).ti,ab.
44	exp Random Allocation/ or exp Double-Blind Method/ or exp Control Groups/ or exp Placebos/ use mesz
45	Randomized Controlled Trial/ or exp Randomization/ or exp RANDOM SAMPLE/ or Double Blind Procedure/ or exp Triple Blind Procedure/ or exp Control Group/ or exp PLACEBO/ use emez
46	(random* or RCT).ti,ab.
47	(placebo* or sham*).ti,ab.
48	(control* adj2 clinical trial*).ti,ab.
49	meta analysis/ use emez
50	(meta analy* or metaanaly* or pooled analysis or (systematic* adj2 review*) or published studies or published literature or medline or embase or data synthesis or data extraction or cochrane).ti,ab.
51	or/41-50
52	(39 and 51) or 40
53	limit 52 to english language
54	limit 53 to yr="2002 -Current"
55	remove duplicates from 54