Search date: August 26, 2012 Databases searched: Ovid MEDLINE, MEDLINE In-Process and Other Non-Indexed Citations, Embase; Wiley; Cochrane; Centre for Reviews and Dissemination (CRD) database Limits: 2002-present; Human; English; NOT case reports, comments, editorials, letters Filters: RCTS & MAs/SRs/HTAs for administration route question (#3) | |
1 | exp Vitamin B 12 Deficiency/ use mesz |
2 | exp Vitamin B 12/df use mesz |
3 | Transcobalamins/df use mesz |
4 | exp Cyanocobalamin Deficiency/ use emez |
5 | ((b12 or b 12 or cyanocobalamin or cobalamin* or transcobalamin* or cobamide? or hydroxocobalamin or hydroxo-cobalamin or hydroxycobalamin) adj3 (deficien* or inadequa* or insufficien* or low blood level* or low serum level* or low plasma level* or suboptimal or sub-optimal or subnormal or sub-normal)).ti,ab. |
6 | (an?emia* adj2 (addison* or pernicious* or megaloblastic)).ti,ab. |
7 | or/1-6 |
8 | exp Vitamin B 12/ use mesz |
9 | Transcobalamins/ use mesz |
10 | Transcobalamin/ use emez |
11 | Cyanocobalamin/ use emez |
12 | (b12 or b 12 or cyanocobalamin or cobalamin* or transcobalamin* or cobamide? or hydroxocobalamin or hydroxo-cobalamin or hydroxycobalamin).ti,ab. |
13 | or/8-12 |
14 | exp Dementia/ |
15 | exp Cognition Disorders/ use mesz |
16 | (alzheimer* or amentia? or dementia* or demention or senile or senility or (cognit* adj (decline or disorder? or impair*))).ti,ab. |
17 | or/14-16 |
18 | (7 or 13) and 17 |
19 | Case Reports/ or Comment.pt. or Editorial.pt. or Letter.pt. |
20 | Case Report/ or Comment/ or Editorial/ or Letter/ |
21 | or/19-20 |
22 | 18 not 21 |
23 | limit 22 to english language |
24 | limit 23 to yr="2002 -Current" |
25 | exp animals/ |
26 | exp animal experimentation/ |
27 | exp models animal/ |
28 | exp animal experiment/ |
29 | nonhuman/ |
30 | exp vertebrate/ |
31 | or/25-30 |
32 | exp humans/ |
33 | exp human experiment/ |
34 | or/32-33 |
35 | 31 not 34 |
36 | 24 not 35 |
37 | remove duplicates from 36 |
38 | 7 and 13 |
39 | 38 not 21 |
40 | limit 39 to (controlled clinical trial or meta analysis or randomized controlled trial) |
41 | exp Technology Assessment, Biomedical/ or exp Evidence-based Medicine/ use mesz |
42 | exp Biomedical Technology Assessment/ or exp Evidence Based Medicine/ use emez |
43 | (health technology adj2 assess$).ti,ab. |
44 | exp Random Allocation/ or exp Double-Blind Method/ or exp Control Groups/ or exp Placebos/ use mesz |
45 | Randomized Controlled Trial/ or exp Randomization/ or exp RANDOM SAMPLE/ or Double Blind Procedure/ or exp Triple Blind Procedure/ or exp Control Group/ or exp PLACEBO/ use emez |
46 | (random* or RCT).ti,ab. |
47 | (placebo* or sham*).ti,ab. |
48 | (control* adj2 clinical trial*).ti,ab. |
49 | meta analysis/ use emez |
50 | (meta analy* or metaanaly* or pooled analysis or (systematic* adj2 review*) or published studies or published literature or medline or embase or data synthesis or data extraction or cochrane).ti,ab. |
51 | or/41-50 |
52 | (39 and 51) or 40 |
53 | limit 52 to english language |
54 | limit 53 to yr="2002 -Current" |
55 | remove duplicates from 54 |