Table A3. Risk of Bias Among Observational Trials for the Association Between Homocysteine and the Onset of Dementia.
| Author, Year | Appropriate Eligibility Criteria | Appropriate Measurement of Exposure | Appropriate Measurement of Outcome | Adequate Control for Confounding | Complete Follow-Up |
|---|---|---|---|---|---|
| Zylberstein et al, 2011 (33) | No limitations | No limitations | No limitations | No limitations | No limitations |
| Seshadri et al, 2002 (34) | No limitations | No limitations | No limitations | No limitations | No limitations |
| Kivipelto et al, 2009 (35) | No limitations | No limitations | No limitations | No limitations | No limitations |
| Nurk et al, 2005 (36) | No limitations | No limitations | No limitations | No limitations | Limitationsa |
| Luchsinger et al, 2004 (37) | No limitations | No limitations | No limitations | No limitations | No limitations |
| Haan et al, 2007 (38) | No limitations | No limitations | Limitationsb | Limitationsc | No limitations |
| Ravaglia et al, 2005 (39) | No limitations | No limitations | No limitations | No limitations | No limitations |
| Wang et al, 2001 (40) | No limitations | No limitations | Limitationsd | No limitations | No limitations |
| Kalmijn et al, 1999 (41) | No limitations | No limitations | Limitationsb | No limitations | No limitations |
| Kim et al, 2008 (42) | No limitations | No limitations | No limitations | No limitations | No limitations |
| Rowan et al, 2007 (43) | No limitations | No limitations | No limitations | Limitationse | No limitations |
a
It is unclear how many patients completed full 6 years of follow-up.
b
Studies reported wide confidence intervals.
c
This analysis was not adjusted for age or sex.
d
This study measured vitamin B12 levels, while all other studies measured homocysteine.
e
It is unclear whether the analysis was adjusted.