Table A6. GRADE Evidence Profile for Comparison of Oral Vitamin B12 and Parenteral Vitamin B12.
| No. of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| Mean vitamin B12 level above cut-off at end of study | |||||||
| 3 (RCTs) | Serious limitations (-1)a | No serious limitations | No serious limitations | No serious limitations | Undetected | None | ⊕⊕⊕ Moderate |
a
The risk of bias assessment identified limitations with each of the randomized controlled trials (see Table A7).
Abbreviation: RCT, randomized controlled trial.