Skip to main content
. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Nature. 2012 Feb 8;482(7385):400–404. doi: 10.1038/nature10755

Figure 2. Affinity value profiles of predicted MHC class I epitopes from tumour-specific mutations.

Figure 2

a, Growth of d42m1 parental cells, a representative sample of tumour clones, and three escape tumours following transplantation into WT mice (n=5, squares). Data are presented as average tumour diameter ± s.e.m. and are representative of three independent experiments. b, Missense mutations for each d42m1-related tumour examined in (a) were analyzed for potential MHC class I neoepitopes that bind either H-2Db or H-2Kb. Predicted epitope binding affinities were ultimately expressed as “Affinity Values” (Affinity Value = 1/IC50 X 100). Arrow is pointing to a H-2Db epitope created by the R913L spectrin-β2 mutant.