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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Curr Opin Microbiol. 2008 Oct 3;11(5):10.1016/j.mib.2008.08.003. doi: 10.1016/j.mib.2008.08.003

Figure 3.

Figure 3

Interactions of macrolides with the ribosome. Erythromycin (red) and tylosin (purple) are shown within their binding sites in the H. marismortui large ribosomal subunit [9,10]. A2451 which marks the location of the peptidyl transferase active site (PTC) is shown in green. Nucleotide residues A2058 and A2059 involved in interactions with desosamine sugar of erythromycin or mycaminose-mycarose disaccharide of tylosin (A2058 and A2059) are shown in cyan. U752 in H. marismortui (A752 in most pathogenic bacteria) interacting with the mycinose sugar of tylosin and likely involved in interactions with alkyl-aryl side chains of ketolides in some bacteria is shown in violet. Loops of ribosomal proteins L4 and L22 approaching the macrolide binding site are shown in beige.