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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Curr Opin Microbiol. 2008 Oct 3;11(5):10.1016/j.mib.2008.08.003. doi: 10.1016/j.mib.2008.08.003

Figure 5.

Figure 5

The bound molecule of erythromycin leaves sufficient space in the exit tunnel for the nascent peptide to squeeze by. The 9 amino acid-long nascent peptide (fMG-I-F-S-I-F-V-I) encoded in the ermCL regulatory ORF was modeled in the exit tunnel of the H. marismortui large ribosomal subunit complexed with erythromycin [10,24]. The erythromycin molecule is shown in red, the nascent peptide is shown in a space-fill representation in olive and CCA end of peptidyl-tRNA in the ribosomal P site is shown as balls-and-sticks (light-green). The A2062 residue of 23S rRNA, which needs to lie flat against the tunnel wall in order to let the nascent peptide slide by the bound macrolide molecule, is shown in blue.