Figure 4. Heterochromatin proteins are found in proximity to nascent DNA in defined order following replication.
Antibodies against Drosophila HP1 protein (a), H3K9 demethylase Su(Var)3–9 (b) and H3K9me3 (d) were used for PLA with PCNA (left column) and for CAA with EdU-labeled DNA (columns 2–5). Red arrows indicate when proteins are first detected in these experiments. A scheme of proposed sequence of formation of heterochromatin is shown in d. The results are from three independent experiments. Scale bar, 10 µm.