. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Heart Fail Clin. 2014 Jan;10(1):10.1016/j.hfc.2013.09.017. doi: 10.1016/j.hfc.2013.09.017

Table 2.

Canonical Pathways from IPA Analysis of CHD Candidate Genes that have major roles in HF

Pathway	Candidate Genes in CHD
Wnt/β-catenin Signaling	SOX2,GJA1,CREBBP
HIF1α Signaling	CREBBP,HRAS,NAA10
Cardiac hypertrophy signaling	NKX2-5,ADCY2,SOS1,CREBBP,HRAS,GATA4
Noonan pathway	SOS1, PTPN11
BMP Signaling Pathway	NKX2-5,SOS1,CREBBP,HRAS,PITX2
TGF-β Signaling	NKX2-5,SOS1,CREBBP,HRAS,PITX2
JAK/Stat Signaling	PTPN11,SOS1,HRAS
RAR Activation	NSD1,ADCY2,CREBBP,PML,CITED2
PPARα/RXRα Activation	ADCY2,SOS1,CREBBP,HRAS,MED12