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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Cell. 2012 Jul 20;150(2):10.1016/j.cell.2012.06.025. doi: 10.1016/j.cell.2012.06.025

Figure 1. Conformational Switch that Really Matters.

Figure 1

(A) Closed and open conformations of E. coli RfaH. (Left) Closed conformation (2oug,a; Belogurov et al., 2007). N-terminal (yellow) and C-terminal (blue) domains are mesh and cartoon. (Right) Homology model (adding 2lcl as a template) of the open conformation (Burmann et al., 2012). N- and C-terminal domains are mesh and cartoon.

(B) Part of the DNA-binding patch of the RfaH N-terminal domain is obscured by interactions with C-terminal domain in the closed conformation. E. coli RfaH (2oug,a) N- and C-terminal domains are mesh and cartoon; DNA-binding patch residues are red sticks (Tyr8, Cys9, Lys10, Gly12, Arg16, Pro52, Asn53, Thr72, and Val75) or red spheres (Leu6, Tyr54, and Val79). The last three are packed against C-terminal domain residues Leu143 and Ile146 (blue spheres).