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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neuropharmacology. 2013 Sep 22;77:10.1016/j.neuropharm.2013.09.010. doi: 10.1016/j.neuropharm.2013.09.010

Figure 1.

Figure 1

Brain 5-HT deficiency leads to increased ETOH consumption in mice. When provided a choice between standard drinking water and a solution of ETOH in 2% sucrose, Tph2KI mice, but not WT, exhibit a significant escalation of ETOH consumption with increasing concentrations of ETOH (A). Both WT and Tph2KI mice have a reduced preference for 12% ETOH compared to 3 and 6% ETOH, but WT mice display a marked aversion to 12% ETOH, whereas Tph2KI animals do not (B). No significant differences in total fluid consumption (C) or in the preference for 2% sucrose or 10% (D) were observed between the genotypes. When provided a choice between 2% sucrose and a solution of ETOH in 2% sucrose, Tph2KI mice consume significantly more ETOH (E) and exhibit an increased preference for ETOH (F). N = 9 per group for A–C. N = 6 per genotype for the 10% sucrose experiment and N = 9 WTs and 10 Tph2KIs for the 2% sucrose experiment for D. N = 8–10 mice per group for E and F. * indicates p < 0.05 compared to Tph2KI 3% ETOH, and ^ indicates p < 0.05 compared to WT 12% ETOH by Tukey’s post hoc tests. $ indicates a main effect of ETOH concentration, ** indicates a significant main effect of genotype, p < 0.05 by two way ANOVA.