Figure 1.

Multilineage differentiation of mesenchymal stem/stromal cells (MSC). Multipotent mesenchymal stem cells (MSC) have been derived from numerous vascularized tissue sources, including bone marrow, adipose, and skeletal muscle tissue, among others. Multilineage differentiation includes osteoblastic, chondrogenic, myogenic, smooth muscle, and neurogenic differentiation. With progressive differentiation toward a mature cell phenotype, often the capacity for differentiation down a competing lineage is lost.