Table 1.
Relevant miRNA in RAAS.
| miRNAs | Tissue/organ/cell line | Source | Target | Functions | Reference |
|---|---|---|---|---|---|
| miR-181a | Kidney | Hypertensive patients | REN, AIFM1 | Hypertension | [33] |
| miR-663 | REN, APOE | ||||
|
| |||||
| miR-155 | Blood | CKD patients | AT1R | Hypertension, cardiovascular disease | [34] |
|
| |||||
| miR-29b, -129-3p, -132, -132-5P and -212 | HEK293N cells, cardiac fibroblasts | Human, Rat | Associated with cardiovascular disease | [35] | |
|
| |||||
| miR-132/212 | Heart, aortic wall, and kidneys | Rat | Associated with blood pressure control | [36] | |
| Artery | ARB-treated patients | ||||
AIFM1: apoptosis-inducing factor, mitochondrion-associated, 1; APOE: apolipoprotein E; AT1R: angiotensin II receptor, type 1; CKD: chronic kidney disease; HEK: human embryonic kidney cells; RAAS: renin-angiotensin-aldosterone system; REN: renin.