Table 4.
Confounders with potential to increase bleeding rates on intravenous heparin therapy in renal transplant and nontransplant patients
Transplant (n = 29) | Nontransplant (n = 29) | |
Home anticoagulant or antiplatelet | 12 (41.4%) | 16 (65.5%) |
Concomitant | ||
Warfarin | 18 (62.1%) | 20 (69%) |
Aspirin | 6 (20.7%) | 10 (34.5%) |
Clopidogrel | 2 (6.9%) | 6 (20.1%) |
Corticosteroid | 29 (100%) | 0 |
Enoxaparin | 8 (27.6%) | 6 (20.7%) |
Surgery during heparin therapy | 16 (55.1%) | 8 (27.6%) |
Mean hemoglobin at heparin initiation, g/dL | 10.8 | 12 |
Mean liver function | ||
AST | 44.7 (range, 15-174) | 44.5 (range, 15-178) |
ALT | 42.3 (range, 10-260) | 44.2 (range, 8-271) |
Total bilirubin | 0.63 (range, 0.2-1.8) | 0.68 (range, 0.2-1.5) |
Mean SCr* | 2.12 (range, 0.6-6.86) | 1.4 (range, 0.43-8.91) |
Note: Values given as n (%), unless otherwise noted. Chi-square analysis was completed for home anticoagulant or antiplatelet therapy, concomitant medications, and presence of surgery. Student t test was used for all laboratory values with a normal distribution, and Mann-Whitney test was used for all laboratory values with a non-normal distribution. ALT = alanine aminotransferase; AST = aspartate aminotransferase; SCr = serum creatinine.
*P = .007.