Table 2.
Fold change of cell cycle regulatory genes mediated by p53 after three days of hyperoxia
| Cell cycle regulatory and apoptosis genes |
Gene symbol |
FC of Nrf2−/−3dO2 lung above Nrf2−/−3dRA |
FC of Nrf2+/+3dO2 lung above Nrf2+/+3dRA |
Description |
|---|---|---|---|---|
| X-linked ectodermal dysplasia receptor | Xedar/ TNFRSF27 |
19.03 | 19.52 | Inhibits cell growth/apoptosis |
| Cyclin-dependent kinase inhibitor 1A | p21 | 8.67 | 10.11 | G1 checkpoint regulator |
| Cyclin G1 | Ccng1 | 4.64 | 4.73 | Cell cycle inhibitor |
| Zinc finger matrin type 3 | Zmat3/Wig1 | 4.48 | 4.86 | Inhibits tumor growth |
| Proline/serine-rich coiled-coil 1 | Psrc1/Dda3 | 5.13 | 4.67 | Promotes cell growth |
| Pleckstrin homology-like domain, family A, member 3 |
PHLDA3 | 3.66 | 3.05 | Regulates AKT |
| Adenylate kinase 1 | AK1 | 3.79 | 3.57 | Growth regulation |
| Sestrin 2 | Sesn2 | 3.35 | 2.99 | Inhibits mTOR |
| Ribosomal protein S27-like | Rps27L | 2.71 | 2.31 | Positively regulates p21 |
| Growth differentiation factor 15 | Gdf15 | 3.48 | 2.79 | Induced in response to stress |
| Glycoprotein (transmembrane) nmb | GPNMB | 3.64 | 2.23 | Growth delay |
| G2 S phase expressed protein 1 | Gtse1 | 2.49 | 2.08 | Regulates p21 stability |
| Transformation related protein 53 inducible nuclear protein 1 |
Trp53inp1 | 2.42 | 2.04 | Regulates cell progression |
| B-cell translocation gene 2, anti- proliferative |
BTG2 | 2.31 | 1.57 | Inhibits cyclin D1 |
| Tumor necrosis factor receptor superfamily, member 10b |
Tnfrsf10b | 3.05 | 3.22 | Apoptosis |
| Apoptosis enhancing nuclease | Aen | 3.84 | 3.16 | Exonuclease involved in apoptosis induction |
| Nuclear protein 1 | Nupr1/p8 | 2.30 | 2.63 | Regulates cell cycle/ apoptosis |
| BCL2-associated x protein | Bax | 2.80 | 2.69 | Apoptosis |
| Prostaglandin-endoperoxide synthase 2 | Ptgs2 | 4.71 | 2.20 | Apoptosis |
| Solute Carrier Family 19, Member 2 | SLC19A2 | 4.81 | 3.77 | Thiamin transporter protein |
| Sulfatase 2 | SULF2 | 4.56 | 2.30 | Regulates signaling pathways |
Numbers indicate fold changes in lungs of Nrf2−/−mice and Nrf2+/+ neonatal mice exposed to 3dO2 above that of Nrf2−/− and Nrf2+/+ RA controls. Fold changes of 1.5 and above/below are significant, p<0.05.