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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: Cell Host Microbe. 2013 Nov 13;14(5):10.1016/j.chom.2013.10.006. doi: 10.1016/j.chom.2013.10.006

Figure 3. Ab-Env Binding, PF and Neutralization of AD8 Variants that Differ in Env Reactivity (ER).

Figure 3

(A) Relationship between Ab binding and inhibition of two AD8 Env variants that differ in the level of ER. Light blue lines are drawn between data points representing the same Ab tested with the two Envs. Abs with an IC50 value greater than 20 µ;g/ml were assigned a neutralization value of 0.05. (B) Fold increase in neutralization sensitivity (1/IC50) of J3Hx(197,HT,N) relative to J3Hx(197) for the indicated Abs and CD4-Ig. The colors of the bars indicate the PF values of the Abs, measured on the AD8 Env. (C,D) Correlations between binding efficiency or PF of Abs measured on the J3Hx(197) Env and fold increase in neutralizing potency (1/IC50) for J3Hx(197,HT,N) relative to J3HX(197). Spearman rank-order correlation coefficient, rS; P value, two-tailed T test.