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. Author manuscript; available in PMC: 2015 Jan 13.
Published in final edited form as: Toxicol Lett. 2013 Nov 2;224(2):10.1016/j.toxlet.2013.10.030. doi: 10.1016/j.toxlet.2013.10.030

Figure 6.

Figure 6

Effect of MMP inhibitor BB-94 on BDL-induced liver injury. WT mice were sham-operated or subjected to BDL for 1 day. Some animals were treated intraperitoneally with 2 doses of 20 mg/kg of the MMP inhibitor Batimastat (BB-94); the first dose was administered just after BDL and the second one 6 hours after BDL. Vehicle-treated mice served as controls. Liver injury was assessed by plasma ALT activities (A) and histologically in H&E stained sections (C). The number of bile infarcts was counted in each tissue section (B). Data are expressed as mean ± SE of n=5 animals per group. *P<0.05 compared with vehicle-treated mice. Magnification, x50.