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. Author manuscript; available in PMC: 2015 Jan 13.
Published in final edited form as: Toxicol Lett. 2013 Nov 2;224(2):10.1016/j.toxlet.2013.10.030. doi: 10.1016/j.toxlet.2013.10.030

Figure 7.

Figure 7

Effect of MMP inhibitor BB-94 on hepatic neutrophil (PMN) accumulation after BDL.WT mice were sham-operated or subjected to BDL for 1day. Some animals were treated intraperitoneally with 2 doses of 20 mg/kg of the MMP inhibitor Batimastat (BB-94); the first dose was administered just after BDL and the second one 6 hours after BDL. Vehicle-treated mice served as controls. Total and extravasated PMNs were counted in 20 high power fields (A) of naphthol-ASD chloroacetate esterase-stained tissue sections (B). Data represent means ± SE of 5 animals per group. *P<0.05 compared with vehicle-treated mice. Magnification, x200. (C) OPN protein levels in bile samples after sham-operation or BDL. Bile samples from pooled sham-operated animals and from individual mice subjected to 1day BDL treated with either vehicle or BB-94 were analyzed for cleaved OPN by western blotting.