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. 2013 Dec;38(12):732, 741-744.

Table 1.

FDA-Approved Indications for Methotrexate

Neoplastic diseases

  • Acute lymphocytic leukemia

  • Breast cancer

  • Chorioadenoma destruens

  • Epidermoid cancers of the head and neck

  • Gestational choriocarcinoma

  • Hydatidiform mole

  • Lung cancer (squamous and small-cell)

  • Meningeal leukemia

  • Mycosis fungoides (advanced; a type of cutaneous T-cell lymphoma)

  • Non-Hodgkin’s lymphoma (advanced stage)

  • Osteosarcoma (non-metastatic; after surgical resection or amputation for the primary tumor)

Autoimmune diseases

  • Polyarticular-course juvenile rheumatoid arthritis (active)

  • Psoriasis (severe, recalcitrant, disabling)

  • Rheumatoid arthritis (severe, active)

Data from methotrexate prescribing information.15