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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Ann Clin Lab Sci. 2012 Fall;42(4):401–408.

Figure 2.

Figure 2

Increased weight loss in select Smad4+/− mice during repeated exposures to dextran sulfate sodium (DSS, 3% w/v dissolved in drinking water). The graph shows average weight percentages compared to 100% on day 0 during the 66 day experiment. A. A group of Smad4+/− animals was resistant to colitis similarly to wild type (WT: n=7) (Smad4+/− a: n=3). B. A second group of Smad4+/− mice lost significant (#: p<0.05 on days 4-14) weight during the first DSS exposure (Smad4+/− b: n=4). C. A third group of Smad4 haploinsufficient mice lost significant weight during the second (#: P<0.05 on day 32) and the third (#: p<0.05 on days 55 and 56) DSS exposure (Smad4+/− c: n=2). * indicates that an animal had to be euthanized early secondary to extreme weight loss. For details see manuscript text. Error bars not shown for clarity. The WT samples are the same in all three panels, but for readability, the different Smad4+/− groups are shown as separate graphs.