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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Lab Invest. 2013 Apr 15;93(6):10.1038/labinvest.2013.52. doi: 10.1038/labinvest.2013.52

Figure 6.

Figure 6

Maximum intensity projection (MIP) magnetic resonance (MR) images of mdr2 knockout (mdr2KO) mice with and without contrast. (a) With acquisition parameters optimized for contrast use (including shorter scan times, which would not be achievable without contrast), use of gadoxetate disodium (right) allows improved visualization of the biliary tree, particularly the intrahepatic ducts (TurboRARE (Turbo Rapid Acquisition with Relaxation Enhancement) with respiratory gating (TR 500) and partial Fourier transform acceleration factor 1.3, echo time 8 ms, effective echo time 16, RARE factor 4, image matrix 256 × 128 × 128 pixels, acquisition matrix 197 × 84 × 100 pixels, resolution 200 μm isotropic, acquisition time 19 min for each scan with respiratory rate of ≈25 breath/min). (b) Accelerated, high-resolution in vivo cholangiography facilitated by gadoxetate disodium-enhancement demonstrating irregular, focally dilated intrahepatic ducts due to multifocal strictures (arrows), consistent with sclerosing cholangitis (TurboRARE with respiratory gating (TR 150) and partial Fourier transform acceleration factor 1.3, echo time 8 ms, effective echo time 16, RARE factor 4, image matrix 512 × 256 × 256 pixels, acquisition matrix 394 × 168 × 198 pixels, resolution 100 μm isotropic, acquisition time 25 min with respiratory rate of ∼25 breaths/min).