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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: J Biol Chem. 2006 Jun 27;281(34):10.1074/jbc.M603877200. doi: 10.1074/jbc.M603877200

FIGURE 8. A model for the regulated translocation of SERT.

FIGURE 8

The bulk of the platelet SERTs are localized in intracellular, Triton X-100 soluble fractions. 5HT mediates the translocation of intracellular SERTs to the plasma membrane associated with the membrane skeleton. The activation and MS localization of SERT are inhibited by citalopram, leading to an accumulation of SERTs in the cytoskeletal-associated fractions and concomitant increase in associations with Hic-5 (CS). The activation of PKC by PMA induces SERT/Hic-5 associations leading to inactivation and translocation to the CS followed by internalization. Both of these processes are inhibited by 5HT.