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. Author manuscript; available in PMC: 2014 Oct 11.
Published in final edited form as: Science. 2013 Oct 11;342(6155):10.1126/science.1241911. doi: 10.1126/science.1241911

Fig. 4. Properties of mouse viral siRNAs produced in vivo.

Fig. 4

(A) Length distribution and abundance of positive- or negative-strand vsRNAs from mice 1 or 2 dpi with NoVΔB2 or with NoV at 4 dpi. (B) Total counts of pairs of complementary 22-nt vsRNAs of NoVΔB2 and NoV in each distance category as defined in Fig. 1B. (C) Virus genome distribution of 21-to 23-nt viral siRNAs sequenced from either sucking mice (top two panels) or BHK-21 cells (bottom two panels) after infection by NoVΔB2. The functional proteins encoded by the viral bipartite RNA genome and transcription of B2 mRNA (RNA3) from RNA1 are shown. Arrows indicate the positions of the four locked nucleic acid probes used to detect negative-strand viral siRNAs in mice.