Table 2. Odds ratios (OR) and 95% confidence intervals (95% CI) from conventional (single exposure and multivariable) and hierarchical logistic regression models (N=2,963a) for continuous nutrient intake in association with breast cancer risk in LIBCSP.
| No. | Nutrient (per day) | Unit of Increaseb | Single exposure | Multivariable | Hierarchical | |||
|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| ORc | 95% CI | ORc | 95% CI | ORc | 95% CI | |||
| 1 | Carbohydrates (g) | 65.30 | 0.96 | 0.82, 1.13 | 1.02 | 0.67, 1.56 | 0.98 | 0.70, 1.37 |
| 2 | Calcium (mg) | 353.35 | 0.99 | 0.90, 1.10 | 1.01 | 0.67, 1.53 | 0.91 | 0.66, 1.24 |
| 3 | Fiber (g) | 5.56 | 0.90 | 0.83, 0.99 | 0.79 | 0.58, 1.08 | 0.83 | 0.64, 1.08 |
| 4 | Magnesium (mg) | 83.74 | 0.88 | 0.78, 0.99 | 0.73 | 0.51, 1.04 | 0.77 | 0.57, 1.04 |
| 5 | Zinc (μg) | 4.23 | 0.97 | 0.87, 1.08 | 0.86 | 0.62, 1.18 | 0.84 | 0.64, 1.11 |
| 6 | Alpha-carotene (μg) | 303.39 | 0.94 | 0.87, 1.01 | 0.91 | 0.75, 1.10 | 0.95 | 0.84, 1.07 |
| 7 | Beta-carotene (μg) | 2435.16 | 0.96 | 0.89, 1.04 | 0.75 | 0.28, 1.97 | 0.98 | 0.65, 1.48 |
| 8 | Cryptoxanthin (μg) | 71.28 | 0.99 | 0.91, 1.07 | 1.06 | 0.91, 1.23 | 1.05 | 0.91, 1.22 |
| 9 | Iron (mg) | 4.41 | 0.94 | 0.83, 1.05 | 1.10 | 0.71, 1.72 | 1.04 | 0.73, 1.48 |
| 10 | Lutein (μg) | 2596.54 | 0.96 | 0.90, 1.04 | 1.02 | 0.71, 1.46 | 0.94 | 0.77, 1.13 |
| 11 | Lycopene (μg) | 1349.84 | 0.95 | 0.87, 1.03 | 0.96 | 0.84, 1.10 | 0.96 | 0.85, 1.08 |
| 12 | Oleic acid (g) | 11.28 | 1.06 | 0.92, 1.24 | 1.21 | 0.84, 1.75 | 1.14 | 0.84, 1.56 |
| 13 | pro-alpha Carotenes (μg) | 2510.63 | 0.96 | 0.89, 1.04 | 1.47 | 0.53, 4.11 | 1.10 | 0.71, 1.70 |
| 14 | Vitamin C (mg) | 77.31 | 0.95 | 0.88, 1.03 | 0.77 | 0.55, 1.07 | 0.85 | 0.66, 1.10 |
| 15 | Vitamin E (a-TE) | 5.00 | 0.98 | 0.90, 1.08 | 0.93 | 0.77, 1.13 | 0.95 | 0.80, 1.14 |
| 16 | Riboflavin (Vit B2) (mg) | 0.75 | 1.00 | 0.90, 1.11 | 0.68 | 0.34, 1.33 | 0.88 | 0.56, 1.36 |
| 17 | Cobalamin (Vit B12)(μg) | 2.85 | 1.03 | 0.94, 1.12 | 1.08 | 0.88, 1.32 | 1.03 | 0.87, 1.23 |
| 18 | Pyridoxine (Vit B6) (mg) | 0.66 | 0.98 | 0.89, 1.08 | 1.18 | 0.87, 1.60 | 1.13 | 0.87, 1.47 |
| 19 | Folate (μg) | 138.92 | 0.97 | 0.89, 1.07 | 1.49 | 1.04, 2.13 | 1.31 | 0.97, 1.76 |
| 20 | Betaine (mg) | 91.17 | 1.03 | 0.94, 1.12 | 1.09 | 0.86, 1.39 | 1.14 | 0.97, 1.35 |
| 21 | Free choline (mg) | 20.81 | 0.94 | 0.83, 1.06 | 1.17 | 0.85, 1.62 | 1.14 | 0.87, 1.49 |
| 22 | Glycerophosphocholine(mg) | 22.71 | 1.03 | 0.94, 1.13 | 1.10 | 0.71, 1.70 | 1.04 | 0.75, 1.45 |
| 23 | Methionine (g) | 0.43 | 1.00 | 0.88, 1.13 | 1.06 | 0.79, 1.43 | 1.10 | 0.86, 1.40 |
| 24 | Free phosphocholine (mg) | 5.10 | 0.98 | 0.89, 1.08 | 1.18 | 0.79, 1.76 | 1.20 | 0.89, 1.63 |
| 25 | Phosphotidylcholine (mg) | 52.23 | 0.94 | 0.86, 1.03 | 0.95 | 0.73, 1.23 | 0.97 | 0.78, 1.20 |
| 26 | Sphingomyelin (mg) | 4.91 | 0.97 | 0.88, 1.07 | 0.93 | 0.65, 1.34 | 0.91 | 0.68, 1.22 |
| 27 | Anthocyanidins (mg) | 7.94 | 0.96 | 0.89, 1.03 | 0.99 | 0.91, 1.07 | 0.98 | 0.91, 1.06 |
| 28 | Flavan-3-ols (mg) | 194.83 | 0.95 | 0.88, 1.02 | 0.99 | 0.55, 1.78 | 0.99 | 0.67, 1.47 |
| 29 | Flavanones (mg) | 33.90 | 0.98 | 0.91, 1.06 | 1.08 | 0.92, 1.27 | 1.05 | 0.91, 1.22 |
| 30 | Flavones (mg) | 0.12 | 0.90 | 0.83, 0.97 | 0.89 | 0.78, 1.01 | 0.90 | 0.79, 1.01 |
| 31 | Flavonols (mg) | 7.33 | 0.93 | 0.86, 1.00 | 1.20 | 0.69, 2.09 | 1.13 | 0.77, 1.65 |
| 32 | Isoflavones (mg) | 8.45 | 1.03 | 0.95, 1.11 | 1.06 | 0.98, 1.15 | 1.06 | 0.98, 1.15 |
| 33 | Lignans (mg) | 4.59 | 0.93 | 0.86, 1.00 | 0.80 | 0.57, 1.11 | 0.84 | 0.64, 1.10 |
a
Note:Excluded those with total energy intake ± 3 SD from the log transformed mean (N excluded = 36) resulting in 1,463 cases and 1,500 controls.
b
Unit of increase corresponds to one standard deviation increase for each nutrient.
c
Odds ratios and corresponding 95% confidence intervals calculated using logistic regression adjusted for age at diagnosis (continuous) and total energy (standard multivariate model)