Table 4.

Odds ratios (OR) and 95% confidence intervals (95% CI) from hierarchical logistic regression models stratified by supplement use for continuous nutrient intake in association with breast cancer risk in LIBCSP.

No.	Nutrient (per day)	Unit of Increasb	Non-supplement usersa (N=915)		Supplement usersa (N=1,071)
			ORc	95% CI	ORc	95% CI
1	Carbohydrates (g)	65.30	1.22	0.75, 1.98	0.89	0.55, 1.42
2	Calcium (mg)	353.35	0.81	0.51, 1.28	0.92	0.60, 1.41
3	Fiber (g)	5.56	0.89	0.59, 1.33	1.02	0.70, 1.47
4	Magnesium (mg)	83.74	0.79	0.49, 1.27	0.73	0.48, 1.09
5	Zinc (μg)	4.23	0.69	0.44, 1.06	0.76	0.50, 1.15
6	Alpha-carotene (μg)	303.39	0.98	0.78, 1.23	0.91	0.75, 1.10
7	Beta-carotene (μg)	2435.16	1.01	0.63, 1.63	0.99	0.63, 1.55
8	Cryptoxanthin (μg)	71.28	1.17	0.92, 1.49	0.92	0.73, 1.15
9	Iron (mg)	4.41	1.08	0.64, 1.80	0.90	0.56, 1.45
10	Lutein (μg)	2596.54	0.80	0.60, 1.07	1.02	0.80, 1.30
11	Lycopene (μg)	1349.84	0.96	0.78, 1.18	1.02	0.84, 1.23
12	Oleic acid (g)	11.28	1.05	0.67, 1.64	1.09	0.70, 1.69
13	pro-alpha Carotenes (μg)	2510.63	1.07	0.66, 1.76	1.04	0.64, 1.67
14	Vitamin C (mg)	77.31	0.79	0.53, 1.18	1.07	0.74, 1.55
15	Vitamin E (a-TE)	5.00	1.05	0.78, 1.42	1.15	0.87, 1.53
16	Riboflavin (Vit B2) (mg)	0.75	1.00	0.58, 1.73	0.88	0.52, 1.50
17	Cobalamin (Vit B12)(μg)	2.85	1.11	0.87, 1.41	1.07	0.80, 1.42
18	Pyridoxine (Vit B6) (mg)	0.66	1.15	0.75, 1.76	0.94	0.65, 1.36
19	Folate (μg)	138.92	0.95	0.61, 1.48	1.35	0.89, 2.05
20	Betaine (mg)	91.17	1.28	0.98, 1.69	1.10	0.86, 1.39
21	Free choline (mg)	20.81	0.89	0.60, 1.32	1.29	0.87, 1.90
22	Glycerophosphocholine(mg)	22.71	0.98	0.63, 1.52	1.23	0.79, 1.89
23	Methionine (g)	0.43	1.07	0.72, 1.60	1.01	0.72, 1.43
24	Free phosphocholine (mg)	5.10	1.44	0.92, 2.26	0.99	0.65, 1.50
25	Phosphotidylcholine (mg)	52.23	0.71	0.51, 1.00	1.06	0.77, 1.46
26	Sphingomyelin (mg)	4.91	1.24	0.80, 1.90	0.84	0.57, 1.24
27	Anthocyanidins (mg)	7.94	1.05	0.89, 1.24	0.95	0.83, 1.09
28	Flavan-3-ols (mg)	194.83	0.88	0.54, 1.43	1.09	0.68, 1.74
29	Flavonones (mg)	33.90	1.08	0.84, 1.40	0.94	0.75, 1.17
30	Flavones (mg)	0.12	0.96	0.77, 1.20	0.94	0.78, 1.14
31	Flavonols (mg)	7.33	1.09	0.67, 1.78	1.04	0.65, 1.66
32	Isoflavones (mg)	8.45	0.98	0.83, 1.16	1.05	0.93, 1.18
33	Lignans (mg)	4.59	0.97	0.65, 1.44	0.91	0.63, 1.32

^aNote: Excluded those with total energy intake ± 3 SD from the log transformed mean (N excluded = 36). Supplement use is available for 1,932 participants (915 non-supplement users and 1,017 supplement users). Supplement use unknown for 977 participants.

^bUnit of increase corresponds to one standard deviation increase for each nutrient.

^cOdds ratios and corresponding 95% confidence intervals calculated using hierarchical logistic regression adjusted for age at diagnosis (continuous) and total energy (standard multivariate model)