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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Pathol. 2013 Sep;231(1):10.1002/path.4229. doi: 10.1002/path.4229

Figure 5.

Figure 5

PTCH1 deletion in human fetal rhabdomyomas (FRM). Fluorescence in situ hybridization testing of PTCH1 revealed homozygous deletion of PTCH1 in tumours FRM4 (lower left panel) and FRM5 (lower middle panel), consistent with large deletions at the PTCH1 locus noted by sequencing. PTCH1 expression in tumour FRM6 (lower right panel) was normal, without evidence of homozygous deletion patterns. Heterozygous deletion patterns in tumours FRM4–6 were within the range observed in normal muscle specimens (upper panels).