Table 1.
Baseline characteristics of the study participants
| Baseline Variables | MCI (n=317) | Normal cognition (n=1610) | p-value |
|---|---|---|---|
| Male sex, N (%) | 186 (58.7) | 803 (49.9) | 0.004 |
| Age (years) -- median (IQR) | 82.7 (79.2, 85.8) | 79.7 (75.2, 83.6) | <.001 |
| Education (years) -- median (IQR) | 12 (12, 15) | 13 (12, 16) | <.001 |
| APOE E4 allele (E24/34/44 vs. 22/23/33), N (%)* | 96 (30.7) | 379 (23.9) | 0.01 |
| Hypertension, N (%) | 254 (80.1) | 1223 (76.0) | 0.11 |
| Stroke, N (%) | 62 (19.6) | 157 (9.8) | <.001 |
| BDI-II Depression (>13), N (%) ** | 45 (15.0) | 124 (8.0) | 0.001 |
| BMI, median (IQR)*** | 26.9 (24.0, 29.8) | 27.20 (24.4, 30.3) | 0.04 |
| Smokers, N (%) | 0.90 | ||
| Never | 156 (49.2) | 811 (50.4) | |
| Current | 15 (4.7) | 69 (4.3) | |
| Former | 146 (46.1) | 730 (45.3) | |
| Coronary artery disease, N (%) | 156 (49.2) | 654 (40.6) | 0.005 |
| Diabetes Mellitus, N (%) | 69 (21.8) | 277 (17.2) | 0.05 |
| COPD, N (%) | 78 (24.6) | 210 (13.0) | <.001 |
Notes: Data are n (%) or median (IQR). IQR = interquartile ratio; BMI = body mass index; BDI = Beck Depression Inventory; COPD = chronic obstructive pulmonary disease; MI = Myocardial infarction
*
25 patients missing APOE e4 status (21 Normal, 4 MCI).
**
75 patients missing BDI-II Depression (59 Normal, 16 MCI).
***
43 patients missing BMI (33 Normal, 10 MCI)