Table 2.
Cross-sectional association between COPD and MCI
| Model 1a | Model 2b | Model 3c | ||||
|---|---|---|---|---|---|---|
| MCI Type | Cases/total N | OR (95% CI) | Cases/total N | OR (95% CI) | Cases/total N | OR (95% CI) |
| Any MCI (n=317) | ||||||
| Men (n=186) | 186/989 | 2.08 (1.41, 3.05) | 172/943 | 2.00 (1.34, 2.97) | 166/916 | 2.12 (1.38, 3.22) |
| Women (n=131) | 131/938 | 1.83 (1.09, 2.99) | 129/909 | 1.73 (1.02, 2.85) | 121/871 | 1.57 (0.88, 2.71) |
| Both sexes | 317/1,927 | 1.98 (1.46, 2.67) | 301/1,852 | 1.90 (1.39, 2.59) | 287/1,787 | 1.87 (1.34, 2.61) |
| Amnestic MCI (n = 229) | ||||||
| Men (n=143) | 143/989 | 1.72 (1.11, 2.61) | 131/943 | 1.72 (1.10, 2.66) | 127/916 | 1.93 (1.20, 3.06) |
| Women (n=86) | 86/938 | 1.96 (1.07, 3.43) | 84/909 | 1.84 (0.99, 3.26) | 78/871 | 1.98 (1.01, 3.68) |
| Both sexes | 229/1,927 | 1.78 (1.26, 2.49) | 215/1,852 | 1.77 (1.23, 2.50) | 205/1,787 | 1.94 (1.32, 2.80) |
| Non-amnestic MCI (n = 88) | ||||||
| Men (n=43) | 43/989 | 2.48 (1.27, 4.71) | 41/943 | 2.23 (1.11, 4.34) | 39/916 | 1.99 (0.94, 4.06) |
| Women (n=45) | 45/938 | 1.37 (0.55, 2.97) | 45/909 | 1.32 (0.52, 2.87) | 43/871 | 0.86 (0.28, 2.10) |
| Both sexes | 88/1,927 | 1.99 (1.18, 3.23) | 86/1,852 | 1.79 (1.05, 2.95) | 82/1,787 | 1.39 (0.77, 2.39) |
COPD = chronic obstructive pulmonary disease; MCI = mild cognitive impairment; OR= Odds ratio
a
Model 1 adjusted for age as a continuous variable, sex where applicable, and education at the baseline.
b
Model 2 additionally adjusted for BDI-II Depression, and history of stroke.
c
Model 3 includes model 2 variables, with additional adjustment for APOEe4 genotype, diabetes, hypertension, coronary artery disease, and BMI.