Table 5.

Predicted percentage of primordial follicles killed as a result of CRT, IMRT, and PRT for the 5 sets of ovaries used in the sensitivity test. Also listed are values of the ratio of relative risk of premature ovarian failure (RRR_POF).

Ovary Set	Primordial follicles killed (%)a			RRRPOF
	CRT	IMRT	PRT	${({\mathit{RRR}}_{\text{POF}})}_{\mathit{CRT}}=\frac{{RR}_{\text{CRT}}}{{RR}_{\text{PRT}}}$	${({\mathit{RRR}}_{\text{POF}})}_{\mathit{IMRT}}=\frac{{RR}_{\text{IMRT}}}{{RR}_{\text{PRT}}}$
Nominal	23.09	15.86	7.71	3.00	2.06
1	18.72	85.04	10.98	1.71	7.75
2	89.89	76.56	9.38	9.58	8.16
3	40.51	60.64	12.96	3.13	4.68
4	23.24	15.89	10.57	2.18	1.49
5	29.38	24.14	8.40	3.50	2.87

^aThe percentages of primordial follicles killed were calculated by using the sum of the therapeutic dose (predicted by the TPS) and the stray radiation dose

Abbreviations: CRT = conventional photon radiotherapy; IMRT = intensity-modulated photon radiotherapy; PRT = proton radiotherapy; TPS = treatment planning system.