TABLE 1.
MIC determined by the NCCLS M27-A method and modified RSA method
| Candida species (no. of isolates) | Druga | MICb (μg/ml)
|
|||||
|---|---|---|---|---|---|---|---|
| NCCLS M27-A
|
Modified RSA
|
||||||
| Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | ||
| C. albicans (45) | FLU | 0.5-64 | 2 | 64 | 0.25-64 | 4 | 64 |
| ITRA | 0.03-16 | 0.5 | 1 | 0.06-16 | 0.5 | 1 | |
| C. glabrata (22) | FLU | 1-64 | 64 | 64 | 1-64 | 64 | 64 |
| ITRA | 0.125-16 | 2 | 16 | 0.25-16 | 2 | 16 | |
| C. krusei (10) | FLU | 8-64 | 32 | 64 | 8-64 | 64 | 64 |
| ITRA | 0.25-2 | 1 | 2 | 1-16 | 1 | 16 | |
| C. parapsilosis (24) | FLU | 0.5-64 | 4 | 64 | 2-64 | 16 | 64 |
| ITRA | 0.125-16 | 0.25 | 16 | 0.125-16 | 0.5 | 16 | |
| C. tropicalis (17) | FLU | 1-32 | 4 | 16 | 2-32 | 8 | 16 |
| ITRA | 0.03-2 | 0.5 | 2 | 0.25-1 | 0.5 | 1 | |
| Total (118) | FLU | 0.5-64 | 4 | 64 | 0.25-64 | 16 | 64 |
| ITRA | 0.03-16 | 0.5 | 1 | 0.06-16 | 0.5 | 2 | |
a
FLU, fluconazole; ITRA, itraconazole.
b
MIC50, MIC for 50% of strains; MIC90, MIC for 90% of strains.