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. Author manuscript; available in PMC: 2013 Dec 30.
Published in final edited form as: Nat Rev Immunol. 2012 Sep;12(9):10.1038/nri3278. doi: 10.1038/nri3278

Figure 3. Context-dependent FOXO transcriptional activity.

Figure 3

The figure shows a schematic representation of the forkhead box O1 (FOXO1) DNA-binding domain (amino acids 150–249) bound to the FOXO consensus DNA sequence (the structural data were obtained from Protein Data Bank entry 3C06 (REF. 71)). The transcriptional activity depends on recruited cofactors, post-translational modifications and cooperative binding, which can have positive (green) or negative (red) effects. FOXO transcription factors bind with differing affinities to DNA sequences related to the consensus site. FOXO factors can also affect chromatin conformation, thereby acting as gateway factors to make gene loci accessible for further regulation. The expectation is that FOXO factors offer unique programmes of gene expression in each distinct cell type.