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. Author manuscript; available in PMC: 2014 Oct 4.
Published in final edited form as: J Proteome Res. 2013 Sep 18;12(10):10.1021/pr4005103. doi: 10.1021/pr4005103

Figure 4.

Figure 4

Age-related increase in GFAP expression in CVN-AD mice. Representative immunopositive staining for GFAP in mouse brain fixed sections from CVN-AD and from wild-type mice at 6, 12, 24 and 42 weeks of age. GFAP immunoreactivity is evident in the cortex (C, arrows), CA1, CA2, and dentate gyrus (DG) at 12 weeks in CVN-AD mice and progresses into the subiculum (S), CA3, and throughout the cortex with age. Scale bars = 500um. I, Data represent the corresponding mean protein intensity found in brain lysates from CVN-AD mice (Supplemental Table S3) ± S.E.M for GFAP at 6, 12, 24, and 42 wks. *p<0.05 compared to 6wks (one-way ANOVA). P-values indicated above horizontal bars correspond to 42wk CVN-AD vs 42wk WT comparison (also found in Table 1).