Table 3. Ethnic differences in major genetic variants associated with lipid levels.

				Han Chinese population a				Japanese population b				European population c
Trait	Gene	SNP	Position	MAF	LD (r2)	P		MAF	LD (r2)	P		MAF	LD (r2)	P
LDL	CELSR2-PSRC1-SORT1 (1p13.3)	rs599839	109623689	0.06	ref	0.015		0.08	ref	NA		0.24	ref	3×10-21
		rs646776	109620053	0.04	0.33	1.23×10-3		0.07	0.85	1.30×10-3		0.24	0.89	3×10-29
		rs12740374	109619113	0.04	0.33	9.31×10-4		0.07	0.85	NA		0.21	0.89	2×10-42
HDL	APOB (2p24.1)	rs673548	21091049	0.26	ref	0.011		0.36	ref	NA		0.24	ref	7.4×10-7
		rs693	21085700	0.06	0.08	0.146		0.09	0.18	NA		0.48	0.23	1.3×10-7
		rs6754295	21059688	0.29	0.85	0.145		0.29	0.72	0.355		0.25	0.86	4.4×10-8

MAF, minor allele frequency; LD, linkage disequilibrium; NA: data not available.

^a The P values in a Han Chinese population were from meta-analysis of two GWAS (DFTJ-cohort and FAMHES) in discovery stage.

^b The P values in a Japanese population were cited from Reference (7).

^c The P values in a European population were cited from Reference (4–6).