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. 2013 Dec 30;8(12):e83168. doi: 10.1371/journal.pone.0083168

Figure 1. Incidence of hypoglycemia, seizures and mortality after insulin IP (15 u/kg) in overnight-fasted PN 28-30 rats; 1 week after STZ (diabetic rats) or CON (controls).

Figure 1

A: Incidence of hypoglycemia in all animals injected with insulin; 68% of STZ (n = 43/63) and 83% of CON (n = 19/23); no statistically significant difference between both groups B: Incidence of seizures in rodents where hypoglycemia was confirmed (BG<3.5 mM); 86% of STZ (n = 37/43) and 100% of CON (n = 19/19); no significant difference exists between the two groups C: Rate of mortality after insulin administration and hypoglycemia; 35% (n = 13/37) of STZ and 42% (n = 8/19) of CON rats. 0% mortality observed in non-seizing STZ (n = 0/26) and CON (n = 0/4) rodents. (*) Denotes a statistically significant difference in survival between seizing and non-seizing rats in the STZ group (p<0.005).