Table 3. Associations between Dicer expression and clinico-pathological variables in IBC.
| Variable | Total | Dicer positive (Intensity 1,2,3) | Dicer negative (Intensity 0) | ?2 | p valueb |
| na (%) | na (%) | na (%) | |||
| Patient age (years) | |||||
| <50 | 131 (29) | 44 (34) | 87 (66) | 0.10 | 0.754 |
| ≥50 | 315 (71) | 101 (32) | 214 (68) | ||
| Histological tumour type | |||||
| Ductal | 345 (78) | 119 (34) | 226 (66) | 2.58 | 0.275 |
| Lobular | 72 (16) | 18 (25) | 54 (75) | ||
| Other | 24 (6) | 7 (29) | 17 (71) | ||
| Tumour grade | |||||
| 1/2 | 305 (69) | 88 (29) | 217 (71) | 9.07 | 0.024 |
| 3 | 134 (31) | 56 (42) | 78 (58) | ||
| Tubule formation score | |||||
| 1 | 25 (6) | 6 (24) | 19 (76) | 1.75 | 0.417 |
| 2 | 52 (13) | 20 (38) | 32 (62) | ||
| 3 | 335 (81) | 106 (32) | 229 (68) | ||
| Nuclear pleomorphism score | |||||
| 1 | 5 (1) | 1 (20) | 4 (33) | 2.52 | 0.284 |
| 2 | 208 (51) | 60 (29) | 148 (56) | ||
| 3 | 199 (48) | 71 (36) | 128 (64) | ||
| Mitotic count score | |||||
| 1 | 265 (64) | 74 (28) | 191 (72) | 8.66 | 0.007 |
| 2/3 | 147 (36) | 58 (39) | 89 (61) | ||
| UICC c T stage | |||||
| pT1 | 121 (28) | 30 (25) | 91 (75) | 4.52 | 0.104 |
| pT2 | 249 (58) | 89 (36) | 160 (64) | ||
| pT3 | 62 (14) | 21 (34) | 41 (66) | ||
| UICC c N stage | |||||
| pN0 | 210 (49) | 71 (34) | 139 (66) | 1.47 | 0.681 |
| pN1 | 119 (28) | 36 (30) | 83 (70) | ||
| pN2 | 65 (15) | 23 (35) | 42 (65) | ||
| pN3 | 32 (8) | 8 (25) | 24 (75) | ||
| Lymphovascular invasion | |||||
| Present | 144 (54) | 46 (32) | 98 (68) | 0.59 | 0.444 |
| Absent | 123 (46) | 34 (28) | 89 (72) | ||
| ER status | |||||
| Positive | 274 (67) | 66 (24) | 208 (76) | 30.31 | <0.001 |
| Negative | 132 (33) | 68 (52) | 64 (48) | ||
| PR status | |||||
| Positive | 236 (57) | 69 (29) | 167 (71) | 3.37 | 0.066 |
| Negative | 180 (43) | 68 (38) | 112 (62) | ||
| HER2 | |||||
| Positive | 64 (14) | 32 (50) | 32 (50) | 10.23 | 0.001 |
| Negative | 380 (86) | 113 (30) | 267 (70) | ||
| Triple negative | |||||
| Yes | 57 (14) | 28 (49) | 29 (51) | 8.47 | 0.004 |
| No | 355 (86) | 106 (30) | 249 (70) | ||
| Molecular subtype | |||||
| Luminal A | 277 (76) | 71 (26) | 206 (74) | ||
| Luminal B | 27 (7) | 10 (37) | 17 (63) | 1.11 | 0.293d |
| HER2 overexpressing | 34 (9) | 21 (62) | 13 (38) | 17.29 | <0.001d |
| Basal-like | 27 (7) | 15 (56) | 12 (44) | 9.43 | 0.002d |
| Ki67 labelling index | |||||
| <10% | 294 (71) | 79 (27) | 215 (73) | 12.16 | <0.001 |
| ≥10% | 119 (29) | 53 (45) | 66 (55) | ||
| BCL2 | |||||
| Positive | 226 (55) | 64 (28) | 162 (72) | 3.18 | 0.074 |
| Negative | 186 (45) | 68 (37) | 118 (63) | ||
| CK14 | |||||
| Positive | 80 (21) | 34 (43) | 46 (57) | 5.04 | 0.025 |
| Negative | 297(79) | 87 (29) | 210 (71) | ||
| CK5/6 | |||||
| Positive | 52 (14) | 21 (40) | 31 (60) | 1.15 | 0.285 |
| Negative | 326 (86) | 107 (33) | 219 (67) | ||
| EGFR | |||||
| Positive | 54 (13) | 31 (57) | 23 (43) | 17.69 | <0.001 |
| Negative | 356 (87) | 102 (29) | 254 (71) | ||
| p53 | |||||
| Positive | 83 (21) | 37 (45) | 46 (55) | 6.75 | 0.009 |
| Negative | 318 (79) | 94 (30) | 224 (70) |
a number of cases for which Dicer expression and data for the relevant parameter was available.
b p values <0.0025 were considered significant when the Bonferroni correction for multiple tests was applied.
c UICC TNM Classification of Malignant Tumours 7th Edition [70].
d compared to luminal A subtype.