Table 1. MIC (µg/mL) of the 15 antimicrobial agents* to the 24 standard NTM strains.
Species(Code) | RIF | INH | STR | AK | KM | CP | OF | LOF | CAP | CEF | DOX | MIN | ETH | PAS | DIP | |
M. abscessus (ATCC19977) | RGM | >256 | >256 | 32 | 32 | 128 | 4 | 32 | 16 | >256 | 64 | >256 | >42.5 | 16 | >256 | >256 |
M. chelonae (NCTC946) | RGM | 64 | >256 | 16 | 32 | 64 | 1 | 4 | 2 | >256 | >256 | >256 | >42.5 | 16 | >256 | >256 |
M. fortuitum (ATCC6841) | RGM | 64 | >256 | 128 | 4 | 8 | <0.25 | <0.25 | <0.5 | >256 | 32 | >256 | >42.5 | 64 | >256 | >256 |
M. peregrinum (ATCC14467) | RGM | 2 | >256 | 32 | <0.5 | 4 | <0.25 | <0.25 | <0.5 | >256 | 8 | 64 | 10.7 | 4 | >256 | >256 |
M. doricum (ATCCBAA565) | RGM | 64 | >256 | 64 | 4 | 16 | <0.25 | 0.5 | <0.5 | >256 | >256 | >256 | >42.5 | 32 | >256 | >256 |
M. obuense (ATCC27023) | RGM | 16 | >256 | <0.5 | 1 | 4 | <0.25 | 0.5 | <0.5 | >256 | >256 | 2 | 1.3 | 8 | >256 | >256 |
M. phlei (ATCC11758) | RGM | <0.5 | >256 | <0.5 | <0.5 | 8 | 0.5 | 1 | <0.5 | >256 | 16 | <0.5 | 3 | 4 | >256 | >256 |
M. duvalii (ATCC43910) | RGM | <0.5 | >256 | <0.5 | <0.5 | 1 | <0.25 | <0.25 | <0.5 | >256 | 8 | <0.5 | 0.3 | 2 | >256 | >256 |
M. parafortuitum (ATCC19686) | RGM | 4 | >256 | <0.5 | 1 | 4 | <0.25 | <0.25 | <0.5 | >256 | >256 | <0.5 | 0.3 | 8 | >256 | >256 |
M. gilvum (ATCC43909) | RGM | <0.5 | >256 | 4 | 1 | 2 | <0.25 | <0.25 | <0.5 | >256 | >256 | 1 | 1.3 | 2 | >256 | >256 |
M. flavescens (ATCC14474) | RGM | 16 | >256 | 2 | <0.5 | 1 | <0.25 | 0.5 | <0.5 | >256 | >256 | 1 | 0.7 | 8 | >256 | >256 |
M. bolletii (CIP 108541) | RGM | >256 | >256 | 128 | 16 | 64 | 8 | 64 | 32 | >256 | 64 | >256 | >42.5 | 16 | >256 | >256 |
M. intracellulare (ATCC13950) | SGM | 2 | >256 | 4 | 4 | 16 | 1 | 16 | 4 | >256 | >256 | 4 | 1 | 8 | >256 | >256 |
M. xenopi (NCTC10042) | SGM | 1 | >256 | 1 | 1 | - | <0.25 | <0.25 | <0.5 | 256 | 64 | <0.5 | <0.08 | 8 | >256 | >256 |
M. senegalense (ATCC35796) | SGM | 2 | >256 | 16 | 2 | 2 | 2 | 4 | 1 | >256 | 16 | 1 | 0.17 | 8 | >256 | >256 |
M. gordonae (ATCC14470) | SGM | <0.5 | >256 | 1 | 2 | 4 | 1 | 2 | 0.5 | 32 | >256 | 4 | 5 | 4 | >256 | >256 |
M. marinum (ATCC927) | SGM | <0.5 | >256 | 4 | 1 | 8 | 4 | 16 | 32 | >256 | 32 | <0.5 | 0.7 | 4 | >256 | 128 |
M. kansasii (ATCC12478) | SGM | <0.5 | >256 | 1 | 4 | 4 | <0.25 | 0.5 | <0.5 | >256 | 8 | 2 | 2.7 | 4 | >256 | >256 |
M. scrofulaceum (ATCC19981) | SGM | 0.5 | >256 | 1 | 2 | 4 | <0.25 | 1 | <0.5 | 4 | >256 | 2 | 1 | 2 | >256 | >256 |
M. malmoense (ATCC29571) | SGM | 1 | >256 | 2 | 2 | 4 | 0.5 | 1 | <0.5 | >256 | >256 | 8 | 5 | 4 | >256 | >256 |
M. avium (ATCC25291) | SGM | 8 | >256 | 1 | 2 | 16 | 2 | 4 | 2 | >256 | >256 | 32 | 11 | 4 | >256 | >256 |
M. szulgai (NCTC10831) | SGM | <0.5 | >256 | 2 | 4 | 8 | 1 | 2 | 2 | >256 | 16 | 4 | 2.7 | 8 | >256 | >256 |
M. terrae (ATCC15755) | SGM | 1 | >256 | 4 | 8 | 16 | <0.25 | <0.25 | <0.5 | >256 | 4 | 8 | 1 | 16 | >256 | >256 |
M. simiae (ATCC25275) | SGM | 8 | >256 | 16 | 8 | 64 | 32 | 64 | 16 | >256 | >256 | >256 | >42.5 | 16 | >256 | >256 |
MIC, minimum inhibitory concentration; NTM, nontuberulous mycobacteria; RGM, rapidly growing mycobacteria; SGM, slowly growing mycobacteria; RIF, rifampicin; INH, isoniazid; STR, streptomycin; AK, amikacin; KM, kanamycin; CP, ciprofloxacin; OF, ofloxacin; LOF, levofloxacin; CAP, capreomycin; CEF, cefoxitin; DOX, doxycycline; MIN, minocycline; ETH, ethionamide; PAS, P-aminosalicylic acid; DIP, dipasic.
bold typeface indicates that the species was susceptible to the antimicrobial drug, while underlining indicates that the species was moderately susceptible to the antimicrobial drug.