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. 2013 Dec 30;8(12):e84892. doi: 10.1371/journal.pone.0084892

Table 1. Characteristics of children in the training and validation groups.

Training group
Validation group
p value
n= 485 % n= 976 %
Neonatal characteristics
Gestational age (weeks)
24-27 weeks 102 (21 220 22 0.57
28-29 weeks 107 (22 229 24
30-32 weeks 276 (57 527 54
Birth weight Z-score
<-1 SD 96 (20) 217 (22) 0.41
(-1 ; 0) SD 204 (42) 477 (43)
> 0 SD 185 (38) 342 (35)
Female 215 (44) 439 (45) 0.83
Mean creatinine ( mg/dl)
24-27 weeks 1.4 (0.7) 1.4 (0.7) 0.27
28-29 weeks 0.8 (0.4) 0.8 (0.3)
30-32 weeks 0.7 (0.4) 0.7 (0.3)
Number of creatinine assessment
24-27 weeks 20 (17) 22 (18) 0.78
28-29 weeks 11 (10) 11 (9)
30-32 weeks 5 (6) 6 (7)
Sodium variation (meq/l)
24-27 weeks 21 (11) 20 (10) 0.98
28-29 weeks 14 (10) 14 (7)
30-32 weeks 9 (6) 9 (6)
Patent ductus arteriosus 59 (12) 119 (12) 0.98
Catecholamine treatment 42 (9) 70 (7) 0.32
Nosocomial infection 123 (25) 280 (29) 0.18
Bronchodysplasia: oxygenotherapy
No oxygen 269 (56) 491 (50) 0.09
< 28 days 131 (27) 323 (33)
28 days- 36 weeks of GA 58 (12) 118 (12)
> 36 weeks of GA 27 (6) 44 (5)
Cerebral lesions 17 (4) 64 (7) 0.02
Neonatal surgery 46 (10) 86 (9) 0.67
Necrotizing enterocolitis 11 (2) 30 (3) 0.38
Neonatal outcome
Death 35 (7) 82 (8) 0.43
Alive 450 (93) 894 (92)
Outcome at 2 years n= 396 (%) n= 784 (%)
Optimal outcome 269 (68) 550 (70) 0.31
Non-optimal outcome 85 (22) 179 (23)
Missing data 35 (9) 51 (7)
Genetic anomalies 6 (2) 2 (3)
death 1 (3) 2 (3)