Table 4. Association between renal impairment and death or non-optimal neurodevelopmental outcomes in the validation set.

	Odds ratio	95% CI	p-value
HSCr > critical values as risk factor for death (n=976)
No adjustment	11.2	(6.9; 18.2)		0.001
Adjustment for GA, birth weight Z-score and sex	8.6	(5.0 ; 14.6)		0.001
Adjustment for GA, birth weight Z-score, sex and risk factors for HSCr > critical values	9.3	(4.7 ; 18.7)		0.001
Adjustment for GA, birth weight Z-score, sex, risk factors for HSCr > critical values and diuretic treatment	9.5	(4.7 ; 19.1)		0.001
Adjustment for GA, birth weight Z-score, sex, risk factors for HSCr > critical values, diuretic treatment and delta natremia	8.8	(4.3 ; 17.8)		0.001
HSCr> critical values as risk factor for Non optimal Outcome (n=729)
No adjustment	2.1	(1.3 ; 3.4)		0.004
Adjustment for GA, birth weight Z-score and sex	1.9	(1.2 ; 3.1)		0.013
Adjustment for GA, birth weight Z-score, sex and risk factors for HSCr > critical values	1.7	(0.97 ; 2.9)		0.063
Adjustment for GA, birth weight Z-score, sex, risk factors for HSCr > critical values and diuretic treatment,	1.7	(0.97 ; 2.9)		0.062
Adjustment for GA, birth weight Z-score, sex, risk factors for HSCr > critical values, diuretic treatment and delta natremia	1.5	(0.85 ; 2.6)		0.16

Abbreviations: HSCr, highest serum creatinineCritical values: 1.6 mg/dL at 24-27 weeks, 1.1 mg/dL at 28-29 weeks, and 1.0 mg/dL at 30-32 weeks)