Table 2. False positive report probability (FPRP) values for nine replicated SNPs between 5,696 GD patients and 5,767 health individuals.
| SNP | Reported P-Value | Reported OR | OR | Statistical power under recessive model * | Prior probability |
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | 0.00001 | |||||
| rs7514649 | 0.0468 | 1.07 | 1.15 | 0.98 | 0.1255 | 0.3009 | 0.8256 | 0.9795 | 0.9979 | 0.9998 |
| 1.20 | 1.00 | 0.1231 | 0.2963 | 0.8224 | 0.9791 | 0.9979 | 0.9998 | |||
| 1.50 | 1.00 | 0.1230 | 0.2962 | 0.8224 | 0.9790 | 0.9979 | 0.9998 | |||
| rs12753075 | 0.4635 | 1.04 | 1.15 | 0.99 | 0.5852 | 0.8089 | 0.9790 | 0.9979 | 0.9998 | 1.0000 |
| 1.20 | 1.00 | 0.5819 | 0.8068 | 0.9787 | 0.9978 | 0.9998 | 1.0000 | |||
| 1.50 | 1.00 | 0.5817 | 0.8066 | 0.9787 | 0.9978 | 0.9998 | 1.0000 | |||
| rs1217223 | 0.0576 | 1.06 | 1.15 | 1.00 | 0.1475 | 0.3416 | 0.8509 | 0.9829 | 0.9983 | 0.9998 |
| 1.20 | 1.00 | 0.1473 | 0.3413 | 0.8507 | 0.9829 | 0.9983 | 0.9998 | |||
| 1.50 | 1.00 | 0.1473 | 0.3413 | 0.8507 | 0.9829 | 0.9983 | 0.9998 | |||
| rs6669008 | 0.0095 | 1.08 | 1.15 | 0.98 | 0.0283 | 0.0803 | 0.4898 | 0.9064 | 0.9898 | 0.9990 |
| 1.20 | 1.00 | 0.0276 | 0.0784 | 0.4836 | 0.9043 | 0.9895 | 0.9989 | |||
| 1.50 | 1.00 | 0.0276 | 0.0784 | 0.4835 | 0.9043 | 0.9895 | 0.9989 | |||
| rs1230647 | 0.0081 | 1.08 | 1.15 | 1.00 | 0.0238 | 0.0682 | 0.4462 | 0.8905 | 0.9879 | 0.9988 |
| 1.20 | 1.00 | 0.0238 | 0.0681 | 0.4455 | 0.8902 | 0.9878 | 0.9988 | |||
| 1.50 | 1.00 | 0.0238 | 0.0681 | 0.4455 | 0.8902 | 0.9878 | 0.9988 | |||
| rs3811021 | 0.0033 | 1.10 | 1.15 | 0.92 | 0.0106 | 0.0310 | 0.2606 | 0.7805 | 0.9727 | 0.9972 |
| 1.20 | 1.00 | 0.0097 | 0.0286 | 0.2448 | 0.7659 | 0.9704 | 0.9970 | |||
| 1.50 | 1.00 | 0.0097 | 0.0285 | 0.2442 | 0.7652 | 0.9703 | 0.9969 | |||
| rs1746853 | 0.0102 | 1.08 | 1.15 | 0.98 | 0.0302 | 0.0854 | 0.5067 | 0.9120 | 0.9905 | 0.9990 |
| 1.20 | 1.00 | 0.0296 | 0.0839 | 0.5018 | 0.9104 | 0.9903 | 0.9990 | |||
| 1.50 | 1.00 | 0.0296 | 0.0839 | 0.5017 | 0.9104 | 0.9903 | 0.9990 | |||
| rs2358994 | 0.0521 | 1.06 | 1.15 | 1.00 | 0.1353 | 0.3194 | 0.8377 | 0.9812 | 0.9981 | 0.9998 |
| 1.20 | 1.00 | 0.1352 | 0.3192 | 0.8376 | 0.9811 | 0.9981 | 0.9998 | |||
| 1.50 | 1.00 | 0.1352 | 0.3192 | 0.8376 | 0.9811 | 0.9981 | 0.9998 | |||
| rs17464525 | 0.0191 | 1.09 | 1.15 | 0.95 | 0.0569 | 0.1532 | 0.6656 | 0.9526 | 0.9950 | 0.9995 |
| 1.20 | 1.00 | 0.0544 | 0.1471 | 0.6548 | 0.9503 | 0.9948 | 0.9995 | |||
| 1.50 | 1.00 | 0.0542 | 0.1468 | 0.6543 | 0.9503 | 0.9948 | 0.9995 | |||
* Statistical power was the power to detect an odds ratio respectively of 1.12,1.20,1.5 for the homozygotes with the rare genetic variant, with an α level equal to the reported P-value. FPRP values below 0.2 were shown in bold letters.