Table 4. Salient Raman spectral peaks of microbicide drugs.
| Drugs | Raman peak (cm-1) a | Tentative assignment b | References |
|---|---|---|---|
| Tenofovir | 725 (vs) c | Adenine, in-phase stretching | [74,75] |
| 1112 (s) d | Phosphate, νs(OPO) | [75,76] | |
| 1311 (ms) | Adenine, ν(C-N), ν(C=N) | [74,75] | |
| 1335 (s) | Adenine/ w(CH2) | [74,77] | |
| 1370 (m) | Adenine, β,γ(C-H) | [74] | |
| 1517 (m) | Imidazole ring, β(C-N-H) | [74,75] | |
| IQP-0528 | 549 (vs) | Uracil,β(C=O) | [78,79] |
| 569 (m) | Uracil, β(C=O) | [78,79] | |
| 670 (mw) | Uracil, γ(N-H) | [79] | |
| 1009 (s) | Uracil, ν(ring) | [74] | |
| 1299 (m) | Uracil, ν(ring) | [74] | |
| 1595 (vs) | Aromatic ring, ν(C-C) | [80] | |
| 1676 (s) | Uracil, ν(C=O) | [78] | |
| Dapivirine | 578 (m) | Mesitylene, β(arene) | [81] |
| 820 (mw) | Mesitylene, γ(C-H) | [81] | |
| 980 (s) | Benzonitrile, ν(C-C) | [82] | |
| 1174 (vs) | Benzonitrile, β(C-H) | [82] | |
| 1610 (s) | Benzonitrile, ν(C-C) | [82] | |
| 2223 (ms) | Benzonitrile, ν(C≡N) | [82] |
a vs, very strong; s, strong; ms, medium-strong; m, medium; mw, medium-weak; w, weak; vw, very weak.
b β, in-plane bending; γ, out-of-plane bending; ν, stretching; r, rocking; w, wagging; s, symmetric; as, anti-symmetric
c Underlined peaks are markers identified for microbicide detection in tissue.
d Absent in Tenofovir