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. 2013 Dec 30;8(12):e85951. doi: 10.1371/journal.pone.0085951

Figure 6. Evaluation of KIF4A protein expression in primary OSCCs.

Figure 6

Representative IHC results for KIF4A protein in normal oral tissue (A) and primary OSCC (B). A, B: Original magnification, ×400. Scale bars, 10 μm. Strong KIF4A immunoreactivity was detected in primary OSCCs; normal oral tissues show almost negative immunostaining. C: The state of KIF4A protein expression in primary OSCCs (n=106) and the normal counterparts. The KIF4A IHC scores were calculated as follows: IHC score = 0× (number of unstained cells in the field) +1× (number of weakly stained cells in the field) +2× (number of moderately stained cells in the field) +3× (number of intensely stained cells in the field). The KIF4A IHC scores for normal oral tissues and OSCCs ranged from 26.5 to 103 (median, 66.5) and 62.3 to 188 (median, 131), respectively. KIF4A protein expression levels in OSCCs are significantly (P < 0.05, Mann-Whitney’s U test) higher than in normal oral tissues.