Table 1. Summary of Claudin expression patterns.
1* | 2 | 3 | 4 | 5* | 8 | 10 | 11 | 12 | 14 | 15 | 16 | 17 | 18 | 22 | 23 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gastrulation (HH4 - HH7) | ||||||||||||||||
Epiblast | ++ | + | + | + | - | + | + | + | + | + | + | + | + | + | + | + |
Mesoderm | - | + | - | + | - | - | + | - | - | - | + | - | + | - | - | + |
Endoderm | + | + | - | + | - | + | + | + | - | + | + | + | + | + | - | + |
Hensen's node | - | + | - | + | - | + | +a | - | - | + | + | + | + | + | - | + |
Extraembryonic ectoderm | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + | + |
Neurulation (HH8-HH12) | ||||||||||||||||
Neural ectoderm | - | + | - | + | - | + | + | - | - | + | + | + | + | + | - | + |
Non-neural ectoderm | + | + | ++ | + | - | + | ++ | ++ | + | + | + | + | + | + | ++ | + |
Pharynx | + | + | ++ | ++ | - | + | - | - | - | ++ | + | + | ++ | + | + | + |
Heart | - | ++ | - | - | - | - | + | - | - | + | - | - | - | - | - | - |
Somites | - | + | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Vasculature | - | - | - | - | ++ | - | - | - | - | - | - | - | - | - | - | - |
Organogenesis (E3-E10) | ||||||||||||||||
Eye epithelium | + | +b | + | + | - | + | +b | - | - | + | + | + | + | + | + | - |
Otic vesicle | +b | - | ++b | + | - | + | + | + | +b | + | +b | + | - | - | - | - |
Nasal epithelium | + | + | + | - | - | +b | +b | +b | +b | +b | +b | +b | +b | +b | - | +b |
Limb ectoderm | + | + | + | + | - | + | + | + | + | + | + | + | + | + | + | + |
Apical ectodermal ridge | + | - | + | + | - | - | - | + | + | - | - | + | - | + | + | - |
Surface ectoderm | + | + | ++b | + | - | + | +b | +b | +b | + | +b | + | + | + | +b | + |
Feather buds | + | - | + | + | - | - | - | - | - | - | - | - | - | - | - | - |
Pancreas | + | - | + | + | - | - | - | + | - | - | - | - | - | - | - | - |
Lung | + | - | + | - | - | - | + | - | - | - | - | - | - | - | - | - |
Kidney | + | - | + | + | - | - | ++ | - | - | - | - | - | - | - | - | - |
Gonad | n/a | - | - | - | - | - | - | ++ | - | - | - | - | - | - | - | - |
Heart | - | + | - | - | - | - | - | + | - | - | - | + | + | - | - | + |
, the expression patterns of Claudin-1 and Claudin-5 have been published previously; -, absent expression; +, positive expression; ++, robust expression ; +a, asymmetric expression; +b, expression with boundaries