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. 2013 Aug 9;4(11):1882–1893. doi: 10.18632/oncotarget.1188

Figure 1. Immunohistochemical detection of ORF2p during murine mammary cancer progression.

Figure 1

A. Structure of a full-length LINE-1 (L1) element. Arrows mark the position of oligonucleotide pairs used for q-PCR and the vertical arrowhead identifies the protein domain recognized by ORF2p-specific antibody. B. Immunohistochemical analysis of LINE-1ORF2p in normal breast (a) and in tumor tissues explanted from transgenic mice at sequential stages of breast cancer development from stage 1 to 6 (b to g). High magnification panels (a' to g') depict the intracellular distribution of LINE-1 ORF2p. Arrows point to positive nuclei for LINE-1 ORF2p.