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. 2013 Oct 7;4(11):1999–2009. doi: 10.18632/oncotarget.1471

Figure 1. HCC gemcitabine-resistant (GR) cells acquired EMT phenotype.

Figure 1

A, MTT assay was performed in parental HepG2, SMMC-7721, HepG2 GR, and SMMC-7721 GR cells, respectively. B, Cell morphology was observed by microscopy. Parental HepG2 and SMMC-7721 cells displayed an epithelioid and cobblestone appearance with little pseudopodia. In contrast, HepG2 GR and SMMC-7721 GR cells showed loss of cell polarity and increased formation of pseudopodia, leading to elongated, irregular fibroblastoid morphology. C, Invasion assay was conducted to measure the invasive capacity in HepG2 and HepG2 GR cells. * P<0.05 vs control. D, Invasion assay was performed to detect the invasive activity in SMMC-7721 and SMMC-7721 GR cells. * P<0.05 vs control.