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. 2013 Oct 14;4(11):2010–2020. doi: 10.18632/oncotarget.1451

Figure 2. GSEA and network analyses reveal NFkB as a potential regulator of disorganization genes.

Figure 2

A) Gene set enrichment analysis [21] finds the gene set ‘positive regulation of IKK and NFkB cascade’ to be enriched among genes that show a high expression in unorganized cells (1:'negatively correlated') and low expression in organized cells in the microarrays (0:'positively correlated') (p=0.09). B) A regulatory network consisting of the 180 genes of the disorganization signature as well as connecting nodes that interact with at least two disorganization genes was identified using Cytoscape. Red nodes: disorganization genes, light blue nodes: connecting genes, green edges: interactions found in NCBI, dark blue node: p65.