Figure 4. Relationship of azacytidine-induced, immune-related pathways to primary lung tumors grouped by expression of IRF7-associated genes.

TCGA samples are ordered by unsupervised clustering based on genes highly up-regulated in H2170, which are enriched for IRF7-targets, represented in the topmost heat map. Order of samples is maintained in all lower heat maps. PD-L1 and IRF7 expression are depicted in the top bar panels as in figure 3D. Supplemental Table 5 table shows the overlaps of genes from each pathway represented in the heat maps. That the observed clustering pattern is not due to chance or batch effect is demonstrated using random sets of 25 genes shown in the bottom two panels.