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. 2013 Dec 20;13(6):283–288. doi: 10.4110/in.2013.13.6.283

Figure 1.

Figure 1

Inhibitory effect of BIRB 796 and AGI 1067 on cytokine production in Raw 264.7 and THP-1 cells. Raw 264.7 and THP-1 cells were pre-incubated with BIRB 796 and AGI 1067 (10µM) for 1 h prior to stimulation of LPS (10 ng/ml) for Raw 264.7 and LPS (1µg/ml) for THP-1 cells. Levels of mouse TNFα (A), mouse IL-1β (B) and human IL-8 (C) were determined by ELISA kits from R&D Systems. Mean±SEM of cytokine levels were measured (**p<0.01; ***p <0.001). Representative data from 1 of 3 independent experiments performed in duplicate are shown.