Figure 1.

Attenuation of acute inflammatory pain in Lcn2 KO mice. (A) Formalin (5%, 10 µl) is administered intraplantarly to the left hindpaw of mice, then nociceptive behavior is measured as shown in the experimental timeline. (B) The behaviors of wild-type (WT) and Lcn2 KO mice are compared for 40 min after the injection. Times spent licking or biting injected hindpaws are recorded. (C) The first 10 min post-injection is defined as the early phase, and the period between 15 and 40 min post-injection as the late phase. The results are means±SEMs. ^*p<0.05, n.s.=not significant (n=7~9).